Nab2 maintains thymus cellularity with aging and stress
نویسندگان
چکیده
منابع مشابه
Identification and characterization of thymus LIM protein: targeted disruption reduces thymus cellularity.
We have identified a novel LIM gene encoding the thymus LIM protein (TLP), expressed specifically in the thymus in a subset of cortical epithelial cells. TLP was identified as a gene product which is upregulated in a thymus in which selection of T cells is occurring (Rag(-/-) OT-1) compared to its expression in a thymus in which selection is blocked at the CD4+ CD8+ stage of T-cell development ...
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Foxn1 Protein Expression in the Developing, Aging, and Regenerating Thymus.
The forkhead box N1 (Foxn1) protein is the key regulator of thymic epithelial cell (TEC) development, yet how Foxn1 functions remains largely unknown. All mature TECs arise from Foxn1-expressing progenitors/immature TECs and it is widely assumed that TECs as a whole are defined by Foxn1 expression. However, data on the Foxn1 protein are virtually lacking. In this study, we developed novel tools...
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ژورنال
عنوان ژورنال: Molecular Immunology
سال: 2017
ISSN: 0161-5890
DOI: 10.1016/j.molimm.2017.02.019